Biomaterials Engineering Sciences

Applying Material Science to Healthcare

Dr. Scott T. Misture

  • Fabrication of CaO-NaO-SiO2/TiO2 scaffolds for surgical applications. A.W. Wren, A. Coughlan, K.E. Smale, S.T. Misture, B.P. Mahon, O.M. Clarkin, M.R. Towler. J. Mat. Sci: Mater. Med. 23:12 2881-2891 2012. 

Dr. Alexis G. Clare

  • Glass Optical Fibers in Medicine. Clare A.G. Glass Tech. Ber. Glass Sci. Technol. 70C: 418-426 1997.
  • The differential response of cultured mammalian cells to commercial silicate glasses. Amy B. Jedlika,  Clare A.G. Sur Act Proc Mat. 101: 219-229 1999.
  • Biomolecular characterization of glass surfaces. Clare A.G. Hall M.M. Korwin-edson M.L., Goldstein A.H. J Phy Cond Mat. 15:31 S2365-S2375 2003.
  • Biospecificity of glass surfaces: streptavidin attachment to silica.  Korwin-edson M.L., Clare A.G., Hall M., Goldstein A.H. J Non-Crys Sol. 349: 260-266 2004.
  • Toughening of dental glass ionomer cements with reactive glass fibres. Lohbauer U., Frankenberger R., Clare A.G., Petschelt A. Greil P. Biomat. 25:(22) 5217-5225 2004.
  • Reactive fiber reinforced glass ionomer cements.  Lohbauer U., Walker J., Nickolaenko S., Werner J, Clare A., Petschelt A., Greil P. Biomat. 24:17 2901-2907 2003.            
  • In-vitro activity of s520 glass fibers and initial assessment of osteoblast attachment. Clupper D.C., Gough J.E., Hall M.M., Clare A.G., Lacourse W.C., Hench L.L. J. Biomed. Mater Res. Part A. 67:1 285-94
  • Influence of glass dissolution products on the detection of proteins by silver staining. Hall M.M. Clare A.G. J Biomed Mat Res Part B. 75B: 435-441 2005.

Dr. Matthew M. Hall

  • In-vitro activity of s520 glass fibers and initial assessment of osteoblast attachment. Clupper D.C., Gough J.E., Hall M.M., Clare A.G., Lacourse W.C., Hench L.L. J. Biomed. Mater Res. Part A. 67:1 285-94
  • Influence of glass dissolution products on the detection of proteins by silver staining. Hall M.M. Clare A.G. J Biomed Mat Res Part B. 75B: 435-441 2005
  • Biomolecular characterization of glass surfaces. Clare A.G. Hall M.M. Korwin-edson M.L., Goldstein A.H. J Phy Cond Mat. 15:31 S2365-S2375 2003.
  • Biospecificity of glass surfaces: streptavidin attachment to silica.  Korwin-edson M.L., Clare A.G., Hall M., Goldstein A.H. J Non-Crys Sol. 349: 260-266 2004.

Dr. Anthony W. Wren

  •  Investigating the Mechanical Durability of Bioactive Glasses as a Function of Structure, Solubility and Incubation Time. Y. Li, A. Coughlan, F.R Laffir, Dimple Pradhan, N.P Mellott, A.W. Wren. Journal of   Non-Crystalline Solids. 380: 25-34 2013.
  • The Effect of Glass Synthesis Route on Setting Behavior and Mechanical Properties of Glass Ionomer Cements I.Y. Kim, C. Ohtsuki, A. Coughlan, L. Placek, A.W. Wren, M.R Towler. J. Mat. Sci: Mater. Med. Accepted Manuscript 2013.
  • Drug-Eluting Composite Materials: A Comparative Study Using Vancomycin and RNPA1000 to Inhibit Growth of Staphylococcus aureus T.M. Eidem, A. Coughlan, M.R. Towler, P.M. Dunman, A.W. Wren. Journal of Biomaterials Applications. Accepted Manuscript2013.
  • Comparison of SiO2-CaO-ZnO-SrO glass polyalkenoate cement to commercial dental materials: ion release, biocompatibility and antibacterial properties. A.W. Wren, A. Coughlan, M.J. German, M.M. Hall, M.R. Towler. J. Mat. Sci: Mat. Med. 24:(9) 2255-64 2013.
  • Characterization of Ga2O3-Na2O-CaO-ZnO-SiO2 Bioactive Glasses. A.W. Wren, T. Keenan, A. Coughlan, F.R. Laffir, D. Boyd, M.R. Towler, M.M. Hall. J. Mat. Sci. 48: 3999-4007 2013.
  •  Aluminium-free glass polyalkenoate cements: Ion release and in-vitro antibacterial efficacy. A.W. Wren, J.P. Hansen, S.   Hayakawa & M.R. Towler. J. Mat. Sci: Mater. Med. 24(5) 1167-78 2013.
  • Comparison of the Weibull characteristics of hydroxyapatite and strontium doped hydroxyapatite. C. Yatongchai, A.W. Wren, D.J. Curran, J-C. Hornez, M.R. Towler. J Mec. Beh. Biomed. Mat. 21C: 95-108 2013.
  • Structure and diffusion of ZnO-SrO-CaO-Na2O-SiO2 bioactive glasses: a combined high energy X-ray diffraction and molecular dynamics simulations study. Y. Xiang, J. Du, A.W. Wren, D.J. Boyd, M. R. Towler. RSC Advances. 3: 5966-5978 2013.
  • Comparison of a SiO2-CaO-ZnO-SrO glass polyalkenoate cement to commercial dental materials: Glass structure and physical properties. A.W. Wren, A. Coughlan, F.R. Laffir, M.R. Towler. J. Mat. Sci: Mater. Med. 24:2 271-280 2013.

  • Fabrication of CaO-NaO-SiO2/TiO2 scaffolds for surgical applications. A.W. Wren, A. Coughlan, K.E. Smale, S.T. Misture, B.P. Mahon, O.M. Clarkin, M.R. Towler. J. Mat. Sci: Mater. Med. 23:12 2881-2891 2012.  
  • Characterization and antibacterial efficacy of silver coated Ca-Na-Zn-Si/Ti glasses. A.W. Wren, B.A. Akgun, B.M. Adams, A. Coughlan, N.P. Mellott, M.R. Towler. J. Biomed. App. 27:4 433-443 2012.  
  • Processing, characterization and bactericidal activity of undoped and silver doped vanadium oxides. M.E. Tousley, A.W. Wren, M.R. Towler, N.P. Mellott. Mat. Chem. & Phys. 137:2 596-603 2012.
  • Gallium containing glass polyalkenoate anti-cancerous bone cements: glass characterization and physical properties. A.W. Wren, A. Coughlan, L. Placek, M.R. Towler. .J. Mat. Sci: Mater. Med. 23: 8 1823-1833 2012.
  • Silver coated bioactive glass particles for wound healing applications. A.W. Wren, A. Coughlan, P. Hassanzadeh, M.R. Towler. .J. Mat. Sci: Mater. Med. 23:5 2012.
  • Solgel derived silver incorporated titania thin films on glass: bactericidal and photocatalytic activity. B.A. Akgun, A.W. Wren, C. Durucan, M.R. Towler, N.P. Mellott, J. Sol-Gel Sci. 59: 2 228-238 2011.
  • The structural role of titanium in Ca-Sr-Zn-Si/Ti glasses for medical applications. A.W. Wren, A. Kidari, F.R. Laffir, M.R. Towler. J Non-Crys. Solids. 357: 3 1021-1026 2011.
  • The bioactivity and ion release of titanium-containing glass polyalkenoate cements for medical applications. A.W. Wren, N.M. Cummins, F.R. Laffir, S.P. Hudson, M.R. Towler. J. Mat. Sci: Mater. Med. 22: 19-28 2011.
  • Raman spectroscopy of fingernails: a novel tool for evaluation of bone quality? N.M. Cummins, J.C.C. Day, A.W. Wren, P. Carroll, N. Murphy, P.M. Jakeman, M.R. Towler. Spec. Biomed. App. 24: 5 517-524 2010.
  • The effect of ionic dissolution products of Ca-Sr-Na-Zn-Si bioactive glass on in vitro cytocompatibility. S. Murphy, A.W. Wren, M.R. Towler, D. Boyd. J. Mat. Sci: Mater. Med. 10: 2827-34 2010.
  • A spectroscopic investigation into the setting and mechanical properties of titanium containing glass ionomer cements. A.W. Wren, N.M. Cummins, A. Kidari, M.R. Towler. J. Mat. Sci: Mater. Med. 21: 8 2355-2364 2010.
  • The effect of biological additives on the material and biological properties of Ca-Sr-Zn-Si glass polyalkenoate cements A.W. Wren, N.M. Cummins, M.R. Towler. J. Mater. Sci. 45: 13 3554-3562 2010 
  • Comparison of antibacterial properties of commercial bone cements/fillers with a zinc-based glass polyalkenoate cement A.W. Wren, N.M. Cummins, M.R. Towler. J. Mater. Sci. 45: 19 5244 2010.
  • Influence of morphology and processing on XPS characterisation of SrO-Ca-ZnO-SiO2 glass. F.R. Laffir, A.W. Wren, M.R. Towler. J. Mater. Sci. 45:11 3102-3105 2010.
  • Antibacterial analysis of a zinc-based glass polyalkenoate cement. O.M. Clarkin, A.W. Wren, R. Thornton, J.C. Cooney, M.R. Towler. J. Biomed. App. 3:277-92 2011.
  • Evaluation of two novel aluminum-free, zinc-based glass polyalkenoate cements as alternatives to PMMA bone cement for use in vertebroplasty and balloon kyphoplasty. G. Lewis, M.R. Towler, D. Boyd, M.J. German, A.W. Wren, O.M. Clarkin, A. Yates. J. Mat. Sci: Mater. Med. 21 59–66 2010.
  • The effect of glass synthesis route on mechanical and physical properties of resultant glass ionomer cements. A.W. Wren, O.M. Clarkin, F.R. Laffir, C. Ohtsuki, I.Y. Kim, M.R. Towler. J. Mat. Sci: Mater. Med.20:10 1991-1999 2009.
  • Fabrication of spherical CaO–SrO–ZnO–SiO2 particles by sol–gel processing. I.Y. Kim, M.R. Towler, A.W. Wren, C. Ohtsuki. J. Mat. Sci: Mater. Med. 20:11 2267-2273 2009.
  • Analysis of γ-irradiated synthetic bone grafts by calorimetry, XRD and 29Si MAS-NMR spectroscopy. D.Boyd, S. Murphy, M.R. Towler, A.W. Wren, S. Hayakawa. J Non-Crys Solids. 355:45-47 2285-2288 2009.
  • Antibacterial properties of a tri-sodium citrate modified glass polyalkenoate cement. A.W. Wren, D. Boyd, R. Thornton, J.C. Cooney, M. R. Towler. J. Biomed. Mat. Res: Part B. 90:2 700-709 2009.
  • The role Sr2+ on the structure and reactivity of SrO-CaO-ZnO-SiO2 ionomer glasses. D. Boyd, M.R. Towler, S. Watts, R.G. Hill, A.W. Wren, O.M. Clarkin. J. Mat. Sci: Mater. Med. 19 953-957 2008.
  • Zinc-based glass polyalkenoate cements with improved setting times and mechanical properties. D. Boyd, O.M. Clarkin, A.W. Wren, M.R. Towler. Acta Biomaterialia. 4 425-431 2008.
  • The processing, mechanical properties and bioactivity of strontium based glass polyalkenoate cements. A.W Wren, O.M. Clarkin, D. Boyd, M.R. Towler. J. Mat. Sci: Mater. Med. 19 1737-1743 2008.
  • TEM analysis of apatite surface layers observed on zinc based glass polyalkenoate cements. D. Boyd, M.R. Towler, A.W. Wren, O.M. Clarkin, D.A. Tanner. J. Mater. Sci. 43 1170–1173 2008.
  • Comparison of an experimental bone cement with surgical simplex P, spineplex and cortoss. D. Boyd, M.R. Towler, A.W. Wren, O.M. Clarkin. J. Mat. Sci: Mat. Med. 19: 4 1745-1752 2008.
  • Raman spectroscopy of the human nail: A potential tool for evaluating bone health? M.R. Towler, A.W. Wren, N. Rushe, J. Saunders, N.M. Cummins, P.M. Jakeman J. Mat. Sci: Mater. Med. 18 759-763 2007.
  • X-Ray Photoelectron Spectroscopy: Studies from Industrial and Bioactive Glasses to Biomaterials. A.W. Wren, F.R. Laffir, N.P. Mellot, M.R. Towler. Alfred University. Nova Publishing. 2010.

Dr. Nathan P. Mellott

  • Characterization and antibacterial efficacy of silver coated Ca-Na-Zn-Si/Ti glasses. A.W. Wren, B.A. Akgun, B.M. Adams, A. Coughlan, N.P. Mellott, M.R. Towler. J. Biomed. App. 27:4 433-443 2012.  
  • Processing, characterization and bactericidal activity of undoped and silver doped vanadium oxides. M.E. Tousley, A.W. Wren, M.R. Towler, N.P. Mellott. Mat. Chem. & Phys. 137:2 596-603 2012.
  • Solgel derived silver incorporated titania thin films on glass: bactericidal and photocatalytic activity. B.A. Akgun, A.W. Wren, C. Durucan, M.R. Towler, N.P. Mellott, J. Sol-Gel Sci. 59: 2 228-238 2011.
  • X-Ray Photoelectron Spectroscopy: Studies from Industrial and Bioactive Glasses to Biomaterials. A.W. Wren, F.R. Laffir, N.P. Mellot, M.R. Towler. Alfred University. Nova Publishing. 2010.

Dr. Yiquan Wu

  • Reinforcement of electrospun membranes using nanoscale Al2O3 whiskers for improved tissue scaffolds. Z. Dong, Y. Wu, Q. Wang, C. Xie, Y. Ren, R.L. Clark. J. Biomed. Mat. Res. Part A. 100: 4 903-910 2012.
  • Mechanical properties and ionic conductivity of electrospun quaternary ammonium ionomers. S. Roddecha, Z. Dong, Y. Wu, M. Anthamatten. J. Mem. Sci. 389: 478- 485 2012.
  • Fabrication of three-dimensional electrospun microstructures using phase modulated femtosecond laser pulses. N. J. Jenness, Y. Wu, R. L. Clark. Mat. Let. 66: 360-363 2012.
  • Thermodynamic modeling and investigation of the formation of electrospun collagen fibers. Z. Dong, Y. Wu, R. ClarkLangmuir. 27: 12417-12422 2011.
  • In-situ formation of Cu metal crystals within nanostructured ZnO electrospun fibers. Y. Wu, Z. Dong, N.J. Jenness, R.L. Clark. Mat. Let. 65: 2683-2685 2011.
  • Femtosecond laser machining of electrospun membranes. Y. Wu, A.Y. Vorobyev, R.L. Clark, C. Guo. App Sur. Sci. 257: 2432-2435 2011.
  • Electrosprayed core-shell microspheres for protein delivery. Y. Wu, I-C. Liao, S. Kennedy, J. Wang, J. Du, K. Leong, R.Clark. Chem Comm.  46: 4743-4745 2010.
  • Template-assisted assembly of electrospun fibers. Y. Wu, Z. Dong, S. Wilson, R. L. Clark.  Polymer. 51: 3244-3248 2010.
  • Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying. Y. Wu, A. MacKay, J. McDaniel, A. Chilkoti, R. L. Clark. Biomacromolecules.10: 19-24 2009.
  • Electrohydrodynamic processing of micro- and nanometer biomaterials: handbook of fabrication and processing of biomaterials. Y. Wu, R.L. Clark. CRC Press /Taylor and Francis Group, pp 275-334 2008.
  • Electrohydrodynamic atomization: a versatile process for preparing materials for biomedical applications. Y. Wu, R.L. Clark.  J. Biomat. Sci: Polymer Edition. 19: 573-601 2008.
  • AFM-based voltage assisted nanoelectrospinning. Y. Wu, M. S. Johannes, R.L. Clark. Mat. Let. 62: 699-702 2008.
  • Control of electrospun mat width through the use of parallel auxiliary electrodes. Y. Wu, L.A. Carnell, R.L. Clark. Polymer. 48: 5653-5661 2007.
  • Controllable porous polymer particles generated by electrospraying. Y. Wu, R.L. Clark. J. Coll. Inter. Sci. 310: 529-535 2007.
  • Laser densification of alumina powder beds generated using aerosol assisted spray deposition. Y. Wu, J. Du, K.-L. Choy, L.L. Hench. J. Euro. Cer. Soc. 27: 4727-4735 2007.
  • Laser densification of tio2 films prepared by aerosol assisted vapour deposition. Y. Wu, K.-L. Choy, L. L. Hench. App. Sur. Sci. 247: 378-383 2005.
  • Preparation of hydroxyapatite fibers by electrospinning technique. Y. Wu, L.L. Hench, J. Du, K.-L. Choy, J. Guo. J. Amer. Cer. Soc. 87:10 1988-1991 2004.


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